Journal article
Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation
BCV Campbell, C Costello, S Christensen, M Ebinger, MW Parsons, PM Desmond, PA Barber, KS Butcher, CR Levi, DA De Silva, MG Lansberg, M Mlynash, JM Olivot, M Straka, R Bammer, GW Albers, GA Donnan, SM Davis
Cerebrovascular Diseases | KARGER | Published : 2011
DOI: 10.1159/000331467
Abstract
Background: Fluid-attenuated inversion recovery (FLAIR) hyperintensity within an acute cerebral infarct may reflect delayed onset time and increased risk of hemorrhage after thrombolysis. Given the important implications for clinical practice, we examined the prevalence of FLAIR hyperintensity in patients 3-6 h from stroke onset and its relationship to parenchymal hematoma (PH). Methods: Baseline DWI and FLAIR imaging with subsequent hemorrhage detection (ECASS criteria) were prospectively obtained in patients 3-6 h after stroke onset from the pooled EPITHET and DEFUSE trials. FLAIR hyperintensity within the region of the acute DWI lesion was rated qualitatively (dichotomized as visually obv..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
[ "The EPITHET study was supported by the National Health and Medical Research Council of Australia, National Stroke Foundation and National Heart Foundation of Australia. The DEFUSE study was funded by National Institutes of Health (NIH) grants RO1 NS39325, Principal Investigator, Gregory W. Albers; K24 NS044848, Principal Investigator, Gregory W. Albers; and K23 NS051372, Principal Investigator Maarten G. Lansberg.", "Bruce Campbell is supported by a National Health and Medical Research Council of Australia postgraduate scholarship 567156, the Heart Foundation of Australia, a Cardiovascular Lipid Australia grant, the Royal Melbourne Hospital Neuroscience Foundation and Victor Hurley Fund. Roland Bammer receives support from NIH grant R01 EB002711." ]